Animal Models Studies

Encouraging results have been obtained with probi-otic therapy in experimental colitis. Administration of Lactobacillus reuteri was shown to significantly reduce inflammation in acetic acid- and methotrex-ate-induced colitis in rats [12,13]. More recently Lac-tobacillus sp. was shown to be able to prevent the development of spontaneous colitis in interleukin-10 (IL-10) deficient mice [14], and continuous feeding with Lactobacillus plantarum could attenuate an established colitis in the same knockout model [15]. A strain of Lactobacillus salivarius (subsp. Saliva rius) reduced the rate of progression from inflammation through dysplasia and colonic cancer in IL-10 deficient mice [16], and a strain of Bifidobacterium, infantis and of Lactobacillus salivarius were able to attenuate inflammation with a reduced ability to produce Th1-type cytokines in the IL-10 knockout model [17]. Using a cocktail of probiotic bacteria (VSL#3), Shibolet and colleagues have shown a significant attenuation of inflammation with a decrease of MPO (myeloperoxidase) and NOS (nitric oxide synthase) activity in iodoacetamide-induced colitis in rats [18], while Madsen and colleagues have reported a significant improvement of inflammation together with a reduction in mucosal levels of proinflammatory cytokines and a normalization of colonic barrier integrity in IL-10 KO mice [19].

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