1 Boris-Lawrie K, Temin HM. The retroviral vector: Replication cycle and safety considerations for retrovirus-mediated gene therapy. Ann NY Acad Sei 1994; 716:59-70. 0*;0; [ PMID 8024209 ]

2 Danos O, Mulligan RC. Expression of retroviral trans-acting functions from complementary crippled genomes: A system for helper free packaging of retroviral vectors. J Cell Biochem 1988; 12:172-178.

3 Nabel EG, Plautz G, Boyce FM, et al. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 1989; 244:1342-1344. [ PMID 2499928 ]

4 Nabel EG, Plautz G, Nabel GJ. Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science 1990; 249:1285-1288. B+S [ PMID 2119055 ]

5 Wilson JM, Birinyi LK, Salomon RN, et al. Implantation of vascular grafts lined with genetically modified endothelial cells. Science 1989; 244:1344-1346. B*sBs [ PMID 2734614 ]

6 Horwitz M. The adenoviruses. In: Fields B, Knipe D, eds. Virology. New York: Raven Press; 1990:1723-1742.

7 Wilson JM. Adenoviruses as gene-delivery vehicles. New Engl J Med 1996; 334:1185-1187.

8 Wickman TJ, Mathias P, Cheresh DA, et al. Integrins 0(vß3 and Ovß5 promote adenovirus internalization but not virus attachment. Cell 1983; 73:309-319.

9 Guzman RJ, Lemarchand P, Crystal RG, et al. Efficient and selective adenovirus-mediated gene transfer into vascular neointima. Circulation 1993; 88:2838-2848. [ PMID 8252697 ]

10 Kass-Eisler A, Falck-Pedersen E, Alvira M, et al. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci USA 1993; 90:11,498-11,502. 0+;0; [ PMID 8265580 1

11 Barr J, Kalynych AM, Tripathy SK, et al. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther 1994; 1:51-58. [ PMID 7584060 ]

12 Lemarchand P, Jones M, Yamada I, et al. In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors. Circ Res 1993; 72:1132-1138. B*;0; [ PMID 8477524 1

13 Guzman RJ, Lemarchand P, Crystal RG, et al. Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ Res 1993; 73:1202-1207. [ PMID 8222091 ]

14 Tripathy SK, Goldwasser E, Lu MM, et al. Stable delivery of physiological levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus. Proc Natl Acad Sci USA 1994; 91:11,557-11,561.

15 Tripathy SK, Black HB, Goldwasser E, et al. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors.

16 Yang Y, Ertl J, Wilson JM. MHC class 1-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994; 1:433-442. B*sHs [ PMID 7533647 ]

17 Yang Y, Li Q, Ertl HC, Wilson JM, et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91:4407-4411. [ PMID 8183921 ]

18 Hartigan-O'Connor D, Amalfitano A, Chamberlain JS. Improved production of gutted adenovirus in cells expressing adenovirus preterminal protein and DNA polymerase. J Virol 1999; 73:7835-7841. [ PMID 10438876 ]

19 Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol 1992; 158:97-129. [ PMID 1316261 ]

20 Rolling F, Samulski RJ. AAV as a viral vector for human gene therapy: Generation of recombinant virus. MolBiotechnol 1995; 3:9-15. ; [ PMID 7606507 ]

21 Kotin R, Linden R, Berns K. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by nonhomologous recombination. EMBO J 1992; 11:5071-5078. [ PMID 1334463 ]

22 Herzog RW, Yang EY, Couto LB, et al. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nature Med 1999; 5(1):56-63.

23 Svensson EC, Marshall DJ, Woodard K, et al. Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors. Circulation 1999; 99:201-205. [ PMID 9892583 ]

24 Felgner PL, Gader TR, Holm M, et al. Lipofectin: A highly efficient, lipid mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987; 84:7413-7417. [ PMID 2823261 ]

25 Bennett CF, Chiang MY, Chan H, et al. Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum. Mol Pharmacol 1992; 41:1023-1033. [ PMID 1352033 ]

26 Zabner J, Fasbender AJ, Moninger T, et al. Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem 1995; 270:18,997-19,007.

27 Nabel EG, Yang Z, Liptay S, et al. Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimal hyperplasia in vivo. J Clin Invest 1993; 91:18221829. [ PMID 8473521 ]

28 Nabel EG, Yang Z, Plautz G, et al. Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo. Nature 1993; 362:844-846. B*;B; [ PMID 7683112 ]

29 Leclerc G, Gal D, Takeshita S, et al. Percutaneous arterial gene transfer in a rabbit model: Efficiency in normal and balloon-dilated atherosclerotic arteries. J Clin Invest 1992; 90:936944. [ PMID 1387886 ]

30 Takeshita S, Gal D, Leclerc G, et al. Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. J Clin Invest 1994; 93:652-661. [ PMID 8113401 ]

31 Kaneda Y, Iwai K, Uchida T. Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science 1989; 243:375-378. B*;Bi [ PMID 2911748 ]

32 Okada Y, Koseki I, Kim J, et al. Modification of cell membranes with viral envelopes during fusion of cells with HVJ (Sendai virus). Exp Cell Res 1975; 93:368-378.

33 Isaka Y, Fujiwara Y, Ueda N, et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-ß or platelet-derived growth factor gene into the rat kidney. J Clin Invest 1993; 92:2597-2601. [ PMID 8254017 ]

34 Morishita R, Gibbons GH, Ellison KE, et al. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sei USA 1993; 90:8474-8478. B*;B; [ PMID 8104336 ]

35 Morishita R, Gibbons GH, Ellison KE, et al. Intimal hyperplasia after vascular injury is inhibited by antisense cdk2 kinase oligonucleotides. J Clin Invest 1994; 93:1458-1464. B-nBi [ PMID 8163650 ]

36 Wolff J, Malone R, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247:1465-1468. [ PMID 1690918 ]

37 Lin H, Parmacek MS, Morle G, et al. Expression of recombinant gene in myocardium in vivo after direct injection of DNA. Circulation 1990; 82:2217-2221. B+;B; [ PMID 2173647 ]

38 Kitsis RN, Buttrick PM, McNally EM, et al. Hormonal modulation of a gene injected into rat heart in vivo. Proc Natl Acad Sei USA 1991; 88:4138-4142. B*;B; [ PMID 2034660 ]

39 Stein CA, Cheng YC. Antisense oligonucleotides as therapeutic agents: Is the bullet really magical? Science 1993; 261:1004-1012. [ PMID 8351515 ]

40 Cohen JS. Oligonucleotide therapeutics. Trends Biotechnol 1992; 10:87-91. [ PMID 1371926 ]

41 Bielinska A, Schivdasani RA, Zhang L, et al. Regulation of gene expression with double-stranded phosphothiolate oligonucleotides. Science 1990; 250:997-1000. B*;Bi [ PMID 2237444 ]

42 Epstein SE, Speir E, Finkel T. Do antisense approaches to the problem of restenosis make sense? Circulation 1993; 88:1351-1353. B+iBi [ PMID 8353896 ]

43 Krieg AM, Yi A, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation.

44 Sullenger BA, Gallardo HF, Ungers GE, et al. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell 1990; 63:601-608. 0+;0i [ PMID 2225067 1

45 Morishita R, Gibbons GH, Horiuchi M, et al. A novel molecular strategy using cis element "decoy" of E2F binding site inhibits smooth muscle proliferation in vivo. Proc Natl Acad Sci USA 1995; 92:5855-5859. B*sHs [ PMID 7597041 ]

46 Plautz G, Nabel EG, Nabel GJ. Introduction of vascular smooth muscle cells expressing recombinant genes in vivo. Circulation 1991; 83:578-583. B*i0i [ PMID 1899366 ]

47 Lynch CM, Clowes MM, Osborne RA, et al. Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: A model for gene therapy. Proc Natl Acad Sci USA 1992; 89:1138-1142. 0*;0; [ PMID 1736297 1

48 Dichek DA, Neville RF, Zwiebel JA, et al. Seeding of intravascular stents with genetically engineered endothelial cells. Circulation 1989; 80:1347-1353. B+sHs [ PMID 2509105 ]

49 Chen S, Wilson JM, Muller DWM. Adenovirus-mediated gene transfer of soluble vascular cell adhesion molecule to porcine interposition vein grafts. Circulation 1994; 89:1922-1928.

50 Yao SN, Smith KJ, Kurachi K. Primary myoblast-mediated gene transfer: Persistent expression of human factor IX in mice. Gene Ther 1994; 1:99-107. B*;0; [ PMID 7584074 ]

51 Barr E, Leiden JM. Systemic delivery of recombinant proteins by genetically modified myoblasts. Science 1991; 254:1507-1509. B+;0; [ PMID 1962212 ]

52 Dhawan J, Pan LC, Pavlath GK, et al. Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science 1991; 254:1509-1512. B>i0i [ PMID 1962213 ]

53 Hamamori Y, Samal B, Tian J, et al. Myoblast transfer of human erythropoietin gene in a mouse model of renal failure. J Clin Invest 1995; 95:1808-1813. B+;0i [ PMID 7706487 ]

54 Barr E, Leiden JM. Somatic gene therapy for cardiovascular diseases: Recent advances. Trends Cardiovasc Med 1994; 4:57-63.

55 Nabel EG. Gene therapy for cardiovascular disease. Circulation 1995; 91:541-548. B+iB [ PMID 7805260 ]

56 Ooboshi H, Welsh MJ, Rios CD, et al. Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue. CircRes 1995; 77:7-13. B+;B [ PMID 7540517 ]

57 Muller DW, Gordon D, San H, et al. Catheter-mediated pulmonary vascular gene transfer and expression. CircRes 1994; 75:1039-1049. [ PMID 7955142 ]

58 Crystal RG. Transfer of genes to humans: Early lessons and obstacles to success. Science 1995; 270:404-410. B+;B [ PMID 7569994 ]

59 Simons M, Edelman ER, DeKeyser JL, et al. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature 1992; 359:67-70. 0-H0; [ PMID 1522889 ]

60 Bennett MR, Anglin S, McEwan JR, et al. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligonucleotides. J Clin Invest 1994; 93:820-828. [ PMID 8113414 ]

61 Shi Y, Fard A, Galeo A, et al. Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury. Circulation 1994; 90:944-951. [ PMID 8044966 ]

62 Simons M, Edelman ER, Rosenberg RD. Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model. J Clin Invest 1994; 93:2351-2356. [ PMID 7911126 ]

63 Mann MJ, Gibbons GH, Kernoff RS, et al. Genetic engineering of vein grafts resistant to atherosclerosis. Proc Natl Acad Sci USA 1995; 92:4502-4506. [ PMID 7753833 ]

64 Mann MJ, Gibbons GH, Tsao PS, et al. Cell cycle inhibition leads to preservation of endothelial function in genetically engineered vein grafts. J Clin Invest 1997; 99:1295-1301.

65 Nabel EG, Shum L, Pompiii VJ, et al. Direct transfer of transforming growth factor f-'l gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci USA 1993; 90:10,57910,763.

66 Pompili VJ, Gordon D, San H, et al. Expression and function of a recombinant PDGF B gene in porcine arteries. Arterioscl Thromb Vase Biol 1995; 15:2254-2264. B-H0i [ PMID 7489251 ]

67 Morishita R, Gibbons GH, Ellison KE, et al. Evidence for direct local effect of angiotensin in vascular hypertrophy: In vivo gene transfer of angiotensin converting enzyme. J Clin Invest 1994; 94:978-984. [ PMID 8083382 ]

68 Nakajima M, Hutchinson HG, Fujinaga M, et al. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: Gain-of-function study using gene transfer. Proc Natl Acad Sci USA 1995; 92:10,663-10,667.

69 Ohno T, Gordon D, San H, et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science 1994; 265:781-784. [ PMID 8047883 ]

70 Chang MW, Ohno T, Gordon D, et al. Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty. Mol Med 1995; 1:172-181. B+sHi [ PMID 8529096 ]

71 Guzman RJ, Hirschowitz EA, Brody SL, et al. In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci USA 1994; 91:10,732-10,736.

72 Simari R, San H, Rekhter M, et al. Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries. J Clin Invest 1996; 98:225-235.

73 Rekhter MD, Shah N, Simari RD, et al. Graft permeabilization facilitates gene therapy of transplant atherosclerosis in a rabbit model. Circulation 1998; 98:1335-1341. [ PMID 9751684 ]

74 Chang MW, Barr E, Seltzer J, et al. Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product. Science 1995; 267:518522. [ PMID 7824950 ]

75 Chang MW, Barr E, Lu MM, et al. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest 1995; 96:2260-2268. [ PMID 7593612 ]

76 Yang Z, Simari R, Perkins N, et al. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc Natl Acad Sci USA 1996; 93:1905-1910.

77 Chen D, Krasinski K, Sylvester A, et al. Down regulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery. J Clin Invest 1997; 99:2334-2341. &H0i [ PMID 9153274 ]

78 Tanner FC, Boehm M, Akyurek LM, et al. Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation.

Circulation 2000; 101:2022-2025. B+S [ PMID 10790340 ]

79 Indolfi C, Avvedimento EV, Rapacciuolo A, et al. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Med 1995; 1:541-545.

80 von der Leyen HE, Gibbons GH, Morishita R, et al. Gene therapy inhibiting neointimal vascular lesion: In vivo gene transfer of endothelial-cell nitric oxide synthase gene. Proc Natl Acad Sci USA 1995; 92:1137-1141. [ PMID 7532305 1

81 Varenne O, Pislaru S, Gillijns H, et al. Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs.

Circulation 1998; 98:919-926. [ PMID 9738648 ]

82 Pu LQ, Sniderman AD, Brassard R, et al. Enhanced revascularization of the ischemic limb by means of angiogenic therapy. Circulation 1993; 88:208-215. [ PMID 8319335 ]

83 Unger EF, Banai S, Shou M, et al. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model. Am J Physiol 1994; 266:H1588-H1595. [ PMID 8184938 ]

84 Takeshita S, Weir L, Chen D, et al. Therapeutic antiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlinb ischemia. Biochem Biophys

Res Commun 1996; 227:628-635. B+sBs [ PMID 8878563 ]

85 Giordano FJ, Ping P, McKirnan MD, et al. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart.

Nature Med 1996; 2:534-539. [ PMID 8616711 ]

86 Koh GY, Kim S, Klug MG, et al. Targeted expression of transforming growth factor-ßl in intracardiac grafts promotes vascular endothelial cell DNA synthesis. J Clin Invest 1995; 95:114-121. B-hH; [ PMID 7529257 1

87 Soonpaa MH, Koh GY, Klug MG, et al. Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science 1994; 264:98-101. B*;B; [ PMID 8140423 ]

88 Milano CA, Allen LF, Rockman HA, et al. Enhanced myocardial function in transgenic mice overexpressing the ß2-adrenergic receptor. Science 1994; 264:582-586. BhE; [ PMID 81600171

89 Mann MJ, Whittemore AD, Donaldson MC, et al. Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: The PREVENT single-centre, randomised, controlled trial.

Lancet 1999; 354:1493-1498. B*;B; [ PMID 10551494 1

90 Isner JM, Pieczek A, Schainfeld R, et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 1996; 348:370-374.

91 Tsurumi Y, Takeshita S, Chen D, et al. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion. Circulation 1996; 94:3281-3290. B*;B; [ PMID 8989142 ]

92 Makino S, Mayazi K, Fuji M, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999; 103:697-705. B+;Bi [ PMID 10074487 ]

93 Leiden JM. Beating the odds: A cardiomyocyte cell line at last. J Clin Invest 1999; 103:591592. B+;B; [ PMID 10074473 ]

94 Riessen R, Isner JM. Prospects for site-specific delivery of pharmacologic and molecular therapies. J Am Coll Cardiol 1994; 23:1234-1244. B+;Bi [ PMID 8144794 ]

95 Nabel EG. Gene therapy for cardiovascular diseases. JNucl Cardiol 1999; 6:69-75. S+;Bi [ PMID 10070842 ]

96 Tanner FC, Yang ZY, Simari RD, et al. Gene transfer and vascular remodeling. In: LaFont A, Topol E, eds. Arterial Remodeling. Boston: Kluwer Academic Publishers; 1997:549-556.

Was this article helpful?

0 0
Your Heart and Nutrition

Your Heart and Nutrition

Prevention is better than a cure. Learn how to cherish your heart by taking the necessary means to keep it pumping healthily and steadily through your life.

Get My Free Ebook

Post a comment