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Chapter 8: CARDIOVASCULAR TISSUE MODIFICATION BY GENETIC APPROACHES SUMMARY AND FUTURE DIRECTIONS

Since the 1980s, there has been remarkable progress in the design of vectors, the enhancement of gene expression by optimizing regulatory units, the development of animal models, and the translation of basic science studies into clinical applications. Despite this progress, there are significant hurdles and challenges that must be met if the promise of gene therapy is to be fulfilled. There is a persistent need for improved vectors that increase transgene expression and program expression specifically to cardiovascular tissues. Cell-specific promoters are being studied. Improved catheters are needed to deliver vectors and transgenes to vascular and myocardial tissues.94 A better understanding of the pathways leading to cardiovascular diseases will permit more careful delineation of candidate target genes. There is no doubt, however, that enthusiasm and optimism remain high that this technology can lead to successful cardiovascular therapies.

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Essentials of Human Physiology

Essentials of Human Physiology

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