Myocyte Relaxation

Myocyte relaxation is a complex process whose rate is determined by three main factors: the kinetics of crossbridge cycling (particularly the rate at which the crossbridges transition from a force-producing to a non-force-producing state), the affinity of Ca ions for TnC, and the activity and affinity of the main Ca reuptake and extrusion mechanisms.64,65 All else being equal, slower kinetics of crossbridge cycling, increased Ca affinity for TnC, and reduced activity of SERCA2 and/or the Na-Ca exchanger slow relaxation. Relaxation is also modulated by the load on the myocyte, at least in part because of the aforementioned dependence of crossbridge cycling kinetics on load. As noted previously, relaxation also may be influenced by restoring forces generated by compression of titin.

Relaxation Audio Sounds Babbling Brook

Relaxation Audio Sounds Babbling Brook

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