Anomalies

Anomalous Origin of the Left Coronary Artery

Occasionally, the left coronary artery is found to arise from the pulmonary artery, and rarely from other aortic arch vessels. The developing coronary vessels perforate the aortic annulus in association with specific immunohistochemical markers, and so it is likely that when this patterning event is altered, anomalies occur.

Abnormal Origin and Course of Coronary Arteries

Numerous variations in the architecture and course of the coronary arteries occur in association with structural cardiovascular malformations. For example, an anomalous origin of the left anterior descending coronary artery from the right coronary artery occurs in association with tetralogy of Fallot. Unfortunately, the mechanisms for these associations have not been defined.

Coronary Arterial Fistulas

Coronary arterial fistulas occasionally occur in isolation and also occur in association with pulmonary valve atresia with an intact ventricular septum. The mechanics responsible for these anomalies are unknown.

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