The oral antidiabetic drugs are of value only in the treatment of patients with type 2 (NIDDM) diabetes mellitus whose condition cannot be controlled by diet alone. These drugs may also be used with insulin in the management of some patients with diabetes mellitus. Use of an oral antidiabetic drug with insulin may decrease the insulin dosage in some individuals. Two oral antidiabetic drugs (eg, a sulfonylurea and metformin) may also be used together when one antidiabetic drug and diet do not control blood glucose levels in type 2 diabetes melli-tus. Figure 49-3 is a pharmacological algorithm indicating the appropriate medication regimen for type 2 diabetes mellitus.
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