The succinimides are contraindicated in patients with known hypersensitivity to the drugs. The succin-imides are contraindicated in patients with bone marrow depression or hepatic or renal impairment and during lactation. Ethosuximide is classified as a
Pregnancy Category C drug and is used with caution during pregnancy. As with all anticonvulsants, when the succinimides are used with other CNS depressants (eg, alcohol, narcotic analgesics, and antidepressants), an additive CNS depressant effect may occur.
When the hydantoins are administered with the suc-cinimides there may be an increase in the hydantoin blood levels. Concurrent administration of valproic acid and the succinimides may result in either a decrease or an increase in succinimide blood levels. When primi-done in administered with the succinimides, lower primidone levels may occur.
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