All antiviral drugs are contraindicated in patients with previous hypersensitivity to the individual antiviral drug. The antiviral drugs are also contraindicated in patients with congestive heart failure, seizures, renal disease, and during lactation. The antiviral drugs are given with caution in patients with renal impairment and require dosage adjustments. Antivirals are used with caution in children, during pregnancy (except ribavirin, a Pregnancy Category X drug), and during lactation.
Other contraindications and precautions are listed below, according to the specific drug. Numerous interactions are possible with the antiviral drugs. Only the most significant interactions are listed for selected drugs. The nurse should consult an appropriate source for a more extensive listing of interactions.
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