Fibric acid derivatives, the third group of antihyperlipi-demic drugs, work in a variety of ways. Clofibrate (Atromid-S), acts to stimulate the liver to increase breakdown of very-low-density lipoproteins (VLDL) to low-density lipoproteins (LDL), decreasing liver synthesis of
VLDL and inhibiting cholesterol formation. Fenofibrate (Tricor) acts by reducing VLDL and stimulating the catabolism of triglyceride-rich lipoproteins, resulting in a decrease in plasma triglyceride and cholesterol. Gemfibrozil (Lopid) increases the excretion of cholesterol in the feces and reduces the production of triglycerides by the liver, thus lowering serum lipid levels.
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