The glucocorticoids are contraindicated in patients with serious infections, such as tuberculosis and fungal and antibiotic-resistant infections.
The glucocorticoids are administered with caution to patients with renal or hepatic disease, hypothyroidism, ulcerative colitis, diverticulitis, peptic ulcer disease, inflammatory bowel disease, hypertension, osteoporosis, convulsive disorders, or diabetes. The glucocorticoids are classified as Pregnancy Category C drugs and should be used with caution during pregnancy and lactation.
Multiple drug interactions may occur with the glucocorticoids. Table 50-2 identifies select clinically significant interactions.
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