Both carvedilol and labetalol are contraindicated in patients with hypersensitivity to the drug, bronchial asthma, decompensated heart failure, and severe brady-cardia. The drugs are used cautiously in patients with drug-controlled congestive heart failure, chronic bronchitis, impaired hepatic or cardiac function, in those with diabetes, and during pregnancy (Category C) and lactation.
When either drug is administered with diuretics and other hypotensives, an increased hypotensive effect may occur. When labetalol is administered with cimetidine, the effects of labetalol are increased. Halothane increases the effects of labetalol. When carvedilol is administered with the antidiabetic drugs, there is an increased effectiveness of the antidiabetic drugs. There is an increased effectiveness of clonidine when carvedilol is administered with clonidine. There is an increased serum level of digoxin when digoxin is administered with carvedilol.
• The Patient Receiving an Adrenergic Blocking Drug
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.