Adverse reactions may occur if the dosage is too high or prolonged, or if withdrawal is too rapid. Administration of fludrocortisone may cause edema, hypertension, congestive heart failure, enlargement of the heart, increased sweating, or allergic skin rash. Additional adverse reactions include hypokalemia, muscular weakness, headache, and hypersensitivity reactions. Because this drug has glucocorticoid and mineralocorticoid activity and is often given with the glucocorticoids, adverse reactions of the glucocorticoids must be closely monitored as well (see Display 50-2).
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