Some of the adverse reactions associated with the administration of centrally acting antiadrenergic drugs include dry mouth, drowsiness, sedation, anorexia, rash, malaise, and weakness. Adverse reactions associated with the administration of the peripherally acting antiadrenergic drugs include hypotension, weakness, light-headedness, and bradycardia.
patients who are mentally depressed. Reserpine is used cautiously in patients with a history of depression, in patients with renal impairment or cardiovascular disease, and during pregnancy and lactation. Guanethidine, another peripherally acting antiadrenergic drug, is con-traindicated in patients with pheochromocytoma and congestive heart failure. The drug is used cautiously in patients with bronchial asthma and renal impairment and during pregnancy and lactation. Anorexiants, haloperidol, the monoamine oxidase inhibitors, tricyclic antidepressants, and phenothiazines decrease the hypotensive effects of guanethidine.
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