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The approaches described in the present chapter have formed the bases for our neurological and neuropsychiatric evaluation of patients who use a number of illegal drugs. As with marijuana users, we have documented the cognitive changes that are present in cocaine abusers (8,57,58). We have reported on blood flow velocity observed in cocaine and opiate abusers to determine the effects of these substances cerebrovasculature (53-55). As mentioned above, all these studies were carried out in the same populations of patients who were observed under identical conditions. It is our hope that a more widespread adaptation of these approaches will help to clarify the pathobiological substrates for the neuropsychiatric disturbances observed in a large number of patients who abuse illicit drugs.

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