Methods for the Synthesis of Cannabinergic Ligands
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Nikas, Richard I. Duclos, Jr., and Alexandros Makriyannis During the last decade, numerous cannabinergic ligands with high affinity and selectivity profiles for cannabinoid receptors CB1 and CB2 emerged from rigorously pursued structure-activity relationship studies. This chapter focuses on the synthetic aspects of key cannabi-noid receptor probes representing the different classes of cannabinergic ligands that encompasses classical cannabinoids CCs including some...
- Acknowledgment
- Acknowledgments - 2 3 4
- Acute Effects - 2 3
- Adle Thomas and Roger G Pertwee
- Adverse Events From Cannabis Administration
- Agonist Stimulated [35SGTPyS Binding to Cell Membrane Homogenates
- Alexander F Hoffman and Carl R Lupica
- Aminoalkylindoles
- Anxiety and Stress
- Appetite and Food Intake
- Applications of Image Analysis in the Study of the CNS Morphology
- Assays Using Electrically Stimulated Tissues
- Assays Using Electrically Unstimulated Tissue
- Assessing Cannabis Craving in a Research Setting
- Associative Processes
- Cannabinoid CB1 Receptor Radioligand Binding
- Cannabinoid Receptors
- Cannabinoid Receptors and Cell Signaling
- Cannabinoids
- CB2R Knockout Mouse
- Cell Cultures Splenocyte Cell Cultures
- Christopher Breivogel
- Chronic Effects - 2
- Cognition Tests
- Conclusions - 2
- Contents
- Contributors
- Cytokine Assays - 2
- Data Analysis
- David A Gorelick and Stephen J Heishman
- Developing
- Diarylpyrazoles
- Dipping of Slides
- Dissection
- Drug Discrimination
- Electroencephalographic
- Endocannabinoid Uptake Studies In Vitro Assay of Endocannabinoid Uptake
- Endocannabinoids
- Ester Fride Alex Perchuk F Scott Hall George R Uhl and Emmanuel S Onaivi
- Film Exposure Development and Dipping of Hybridized Slides
- Filomena Fezza Natalia Battista Monica Bari and Mauro Maccarrone
- Fixation
- Future Directions
- Gene Structure and Expression Studies
- General Aspects
- George R Uhl Hiroki Ishiguro Emmanuel S Onaivi PingWu Zhang B Emmanuel Akinshola Zhicheng Lin Bruce Hope Claire M Leonard and Qing Rong
- Guy A Cabral
- Humana Press Totowa New Jersey
- Hybrid Cannabinoids
- Immunoblotting of Cannabinoid Receptors
- Immunocytochemistry
- In Vitro and In Vivo Gastrointestinal Secretion Studies
- In Vitro Peristalsis Studies in Isolated Intestine
- In Vitro Studies on Isolated Gastrointestinal Muscle Preparations
- In Vitro Transcription - 2
- In Vivo Gastrointestinal Motility Studies
- Index
- Info
- Introduction - 2 3 4 5 6 7 8 9 10 11 12 13 14 15
- Odm
- Jean Lud Cadet Karen Bolla and Ronald I Herning
- M E T H O D S I N M O L E C U L A R M E D I C I N E
- Materials - 2
- Materials 21 Cell Cultures 3 4 5 6 7 8 9 10 11
- Measurement of Cannabis Effects
- Methods - 2
- Methods 31 Treatment
- Methods for Double and Single Label In Situ Hybridization Andrea G Hohmann
- Methods to Study the Behavioral Effects and Expression of CB2 Cannabinoid Receptor and Its Gene Transcripts in the Chronic Mild Stress Model of Depression
- Microarray Analysis
- Mitogen Activated Protein Kinase Assay - 2
- Modification of Gene Expression in Xenopus laeves Oocytes
- Morphometric Measurement
- Nancy E Buckley Diep Burbridge Manop Buranapramest Tanya Ferguson and Renee Y Paau
- Nissar A Darmani
- Nonclassical Cannabinoids
- Notes - 2 3 4 5 6 7 8
- Orexigenic and Anorexigenic Studies
- Patricia Tagliaferro Alberto J Ramos Emmanuel S Onaivi Sergio G Evrard Maite Duhalde Vega and Alicia Brusco
- Phagocytosis Assay - 2
- Postnatal Development
- Preface
- Preparation of Cell Membrane Homogenates
- Preparation of Synaptosomes
- Processing of Cells and Tissues for Electron Microscopy
- Radiochromatographic Assay of FAAH Activity
- References - 2 3 4 5 6 7 8 9 10
- Research Subjects
- Reward and Reinforcement
- Riboprobe Hybridization
- Robert I Block
- Some Interpretational Difficulties
- Splenocyte and TCell Proliferation Assay
- Splenocyte and TCell Proliferation Assays
- Statistics
- Stephen J Heishman and Edward G Singleton
- TCD Sonography
- The CMS Model of Depression
- The Mouse Tetrad Test
- Timemin
- Tissue Preparation Prior to Hybridization
- Tissue SetUp
- Visualization of Digoxigenin Labeled mRNA
- Vomiting Studies
- Washing of Tissue Following Hybridization
- [35SGTPyS Binding to Intact Cultured Cells
- [35SGTPyS Cell Binding Procedure