The prognosis for a patient with recurrent or progressive retinoblastoma depends on the site and extent of the recurrence or progression. Responses as high as 85% have been reported following treatment with etoposide and carboplatin. If the recurrence or progression of retinoblastoma is confined to the eye and is small, the prognosis for sight and survival may be excellent with local ophthalmic therapy only. If the recurrence or progression is confined to the eye but is extensive, the prognosis for sight is poor; however, the survival remains excellent. If the recurrence or progression is extraocular, the prognosis is more guarded and the treatment depends on many factors and individual patient considerations.
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