Severe aplastic anemia is defined as a bone marrow cellularity of less than 25% and at least two of the following findings: granulocyte count, <500/mm3 (<200/mm3 in very severe aplastic anemia); platelet count, <20,000/mm3; and reticulocyte count, <40,000/mm3. The definition of mild and moderate aplastic anemia varies among researchers and institutions.

Table 6-18 lists the recommendations for the treatment of moderate and severe aplastic anemia. Table 6-19 lists the favorable and unfavorable prognostic factors in acquired aplastic anemia.

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