S

Sacrococcygeal teratoma. See Teratoma Sarcoma. See also Rhabdomyosarcoma clear cell, of kidney, 551t, 559 Sarcoma botryoides, 564t, 567 SCD. See Sickle cell disease (SCD) Schilling test, 51t, 67 Schistocytes, abnormalities in anemia, 6t Schulman Syndrome, 241 Scleroderma, with Hodgkin disease, 465 Sclerosis, nodular, Hodgkin disease, 455t Scurvy, hematologic manifestations, 85 Sebastian syndrome, 287t

Serum iron and iron saturation percentage, in iron deficiency anemia, 39 Serum transferrin receptor levels (STR), measure of iron deficiency, 39-40 Shwachman-Diamond syndrome, 221-222

hematologic manifestations, 73 Sickle cell disease (SCD), 157-181 clinical features by age, 159f, 161-169 crises, 159f, 159-161t aplastic crisis, 159-160 differentiation between bone infarction and osteomyelitis, 160t differentiation between painful abdominal crisis and acute abdomen, 161t differentiation between pneumonia and pulmonary infarction, 161t erythroblastopenic crisis, 159-160 hyperhemolytic crisis, 161 painful crisis, 172-173

splenic sequestration crisis, 160, 172, 174t vaso-occlusive crisis, 160t, 161t diagnosis, 170, 1711 genetics, 157

health maintenance-related laboratory studies, 175t hematology findings, 158 hemostatic changes, 169 incidence, 157 management, 172-176 acute chest syndrome, 1751 hematopoietic stem cell transplantation,

177-188 hydroxyurea therapy, 176 new treatment modalities, 176 pain crisis dose and interval of analgesics for adequate pain control, 173t serum a-hydroxybutyric dehydrogenase, 173t in pregnancy, 175-176 prognosis, 170

protocol, patients under 5 years of age, with fever, 1721 psychological support, 176 sickle cell trait, 178-179 splenic sequestration crisis, 160, 172, 174t transfusion therapy, 174 neurologic deficit, 162t organ dysfunction, 161-169 pathophysiology, 157-158, 158/ Sickle cell trait (heterozygous form, AS),

178-179 Sideroblastic anemia, 126-129 classification, 126-127t iron and heme metabolism: distinct features in erythroid cells, 128t pathophysiology, 127-128 treatment, 128-129 Sideroblastic bone marrow morphology, 10/ Sinovenous thrombosis, therapy, 361 Skin, in SCD, 167

Skin disease, hematologic manifestations, 76 Sodium ferric glutonate, for iron-deficiency anemia, 45

Soft-tissue sarcomas. See also Rhabdomyosarcoma (RMS)

nonrhabdomyosarcoma soft-tissue sarcomas (NRSTS), 561, 562-563t Spermatogenesis, late effects of childhood cancer, 766, 767t

Spherocytes, abnormalities in anemia, 5t Spherocytosis, hereditary, 143-147 biochemistry, 145

classification of and indications for splenectomy, 146t clinical features, 145 complications, 145 diagnosis, 145 genetics, 143 hematology, 144 pathogenesis, 143 treatment, 147 Spinal cord compression, 703-704

Spinal tumors. See Central nervous system (CNS):

malignancies Splenic index in Hodgkin disease, 460 Splenectomy

P-thalassemia, 187

in congenital dyserythropoietic anemia, 101 immune thrombocytopenia, 262-263 indications for, hereditary spherocytosis, 146t Splenomegaly, 367-370 causes, 368t diagnostic approach detailed history, 367 laboratory investigations, 369-370 physical examination, 369 with Hodgkin disease, 460 visceroptosis of spleen, 367 Stem cell transplantation. See Hematopoietic stem cell transplantation (HSCT) Steroid treatment, immune thrombocytopenia, 258-259

Stomatocytes, abnormalities in anemia, 6-7t Stomatocytosis, hereditary, 149-150 Storage pool deficiencies, 286 Streptokinase, 359 Stroke, antithrombotic therapy, 361

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