1. Diagnosis at an early age (<2 years of age) carries a better prognosis (survival 70-75%) than diagnosis at more than 2 years of age (survival 20-45%).
2. Survival is better for patients with stage I or II disease (85%) compared to stage III or IV disease (0%).
3. Synchronous tumors have a better outlook than metachronous tumors.
Table 19-7. Percentage of Event-Free Survival (EFS) and Overall Survival (OS) for Favorable Histology
Stage I-III 86 96
Stage IV 72 86
Stage I-III 86 95
Stage IV 69 81
Modified from D'Angio GJ. Med Pediatr Oncol 2003;41:545-9.
*Calvert formula: For dose of carboplatin 4x (glomerular filtration rate +25) in mg.
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