Prognosis

Historic prognostic factors used to stratify therapy include:

1. Response to initial therapy

2. Age at diagnosis (<24 months, 55-60% mortality)

3. Number of organs involved at diagnosis:

Number of organs Mortality (%)

7-8 100

4. Organ dysfunction (e.g., lung, liver, bone marrow) at diagnosis:

Organ dysfunction

Mortality (%)

Present

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