Primary Tumor Site

The outcome varies with the location of the primary tumor.

Favorable:

1. Head and neck, orbit (nonparameningeal)

2. Genitourinary (excluding prostate and bladder).

Unfavorable:

1. Extremity

2. Bladder and prostate

3. Cranial parameningeal

4. Other (trunk, pelvis-perineum, retroperitoneum, and paravertebral).

Based on site, extent of resection, and histology, patients are now stratified as low, intermediate, or high risk and treated accordingly. Table 20-11 shows the 3-year FFS and overall survival (OS) by risk stratification from IRS-III and IRS-IV data.

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