Primary Tumor Site

The outcome varies with the location of the primary tumor.


1. Head and neck, orbit (nonparameningeal)

2. Genitourinary (excluding prostate and bladder).


1. Extremity

2. Bladder and prostate

3. Cranial parameningeal

4. Other (trunk, pelvis-perineum, retroperitoneum, and paravertebral).

Based on site, extent of resection, and histology, patients are now stratified as low, intermediate, or high risk and treated accordingly. Table 20-11 shows the 3-year FFS and overall survival (OS) by risk stratification from IRS-III and IRS-IV data.

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