Pathology

Hepatomas are divided into two major histologic types: hepatoblastoma and hepatocellular carcinoma. The pathologic classification is as follows:

1. Hepatoblastoma a. Epithelial type i. Embryonal pattern ii. Fetal pattern

Table 24-13. Disorders Associated with Increased Risk of Hepatoblastoma and Hepatocellular Carcinoma

Table 24-13. Disorders Associated with Increased Risk of Hepatoblastoma and Hepatocellular Carcinoma

Hepatoblastoma

Hepatocellular carcinoma

Von Gierke disease

Cirrhosis in infants and children

Congenital cystathioninuria and

Familial cholestatic cirrhosis of childhood

hemihypertrophy

Biliary cirrhosis due to bile duct atresia

Maternal use of hormonal therapy

Cirrhosis following giant cell hepatitis

Exposure to metals such as in

Chronic carrier of hepatitis B virus

welding and soldering fumes

Hereditary tyrosinemia

Beckwith-Wiedemann syndrome

Androgen therapy

Li-Fraumeni syndrome

Methotrexate

Trisomy 18

^-Antitrypsin deficiency

Fetal alcohol syndrome

Fanconi anemia

Gardner syndrome"

Type 1 glycogen storage disease

Type I glycogen storage disease

Neurofibromatosis

Prader-Willi syndrome

Soto syndrome

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