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Packed red cell transfusion in Diamond-Blackfan anemia, 99 in iron deficiency anemia, 45 Pain management in childhood cancer, 728-735

analgesic medications, dosage and frequency, 730-735, 730t adjuvant analgesics, examples and dosages, 733t anesthesia for painful procedures, 731, 734-735

opioid analgesic initial dosage, 732t opioid side effects, management of, 734t opioid therapy for persistent pain, 733t patient-controlled analgesia, 731 causes of, 728

chemotherapeutic agents, percentage dose of, 729t nonpharmacologic methods, 728, 730 sickle cell disease, 172-174, 173t Pancreatic insufficiency (Shwachman-Diamond syndrome), in neutropenia, 73, 221-222 Pancreatitis, hemorrhagic, 73 Pancytopenia complication of stem cell transplantation, 685 differential diagnosis of, 105/ investigations in patients with, 106t Parasitic illnesses with marked hematologic sequelae, 84-85 Parenteral therapy, iron-deficiency anemia, intravenous, 45 Parinaud Syndrome, 514 Paris-Trousseau syndrome, 252t, 277 Paroxysmal nocturnal hemoglobinuria (PNH) clinical manifestations, 131-132, 131t complications, 132 course of the disease, 132 diagnosis flow cytometric analysis of GPI-linked molecules, 132-133 laboratory findings, 133t mechanism of defective hematopoiesis, 131 mechanism of hemolysis and hemoglobinuria, 131

mechanism of hypercoagulable state, 131 pathogenesis, 129-131 treatment, 133-134

surface proteins missing on blood cells, 130t Parvovirus B19, 78-79 Pathogens, in children with cancer, 705t Pearson syndrome, 126t, 128-129 hematologic manifestations, 73 Pediatric Oncology Group POG-8651 protocol for osteosarcoma, 590, 592/ Periodontitis, juvenile, 230 Pernicious anemia, congenital and acquired defects of vitamin B12 absorption, 50, 51t, 52 Petechiae, 17, 254, 255t Peutz-Jeghers syndrome, colon cancer, 73 Phlebotomy, prophylactic, congenital dyserythropoietic anemia, 101 Phosphofructokinase deficiency, 153 Phosphoglycerate Kinase deficiency, 153 Photoablation, retinoblastoma, 638 Physical inactivity, cardiovascular disease and,

338 Pica, 36t

Plasma VFW deficiency, 283t, 285 Plasmapheresis, immune thrombocytopenia, 262

Plasmapheresis with immunoadsorption, 319 Plasminogen activator Inhibitor 1, 337 Plasminogen activator inhibitor deficiency, 348 Platelet aggregation defects acetylsalicylic acid (ASA) and, 288 disorders causing, 289t evaluation of platelets and platelet function in platelet-rich plasma, 292-293 in whole blood, 293 Platelet arachidonic acid pathways, abnormalities in, 287 Platelet count in iron deficiency anemia, 38 normal values, 787t Platelet disorders, 250-294

associated with cardiac disease, 72 hereditary disorders of platelet function,

328-329, 329t laboratory evaluation of platelets and platelet function, 292-293 platelet size, diseases based on, 251t qualitative acquired, 288-289, 289t congenital, 282-288 classification, 283t laboratory findings, 284t drugs implicated in platelet dysfunction, 290t management of defects in platelet function, 289-290

Platelet procoagulant activity, deficiency of, 283t, 288

Platelet receptor-agonist interaction, 283, 285 Platelet secretion disorders, 286-287, 287t Platelet transfusions, immune thrombocytopenia,

262, 720-721t Platelet vessel-wall interaction, 285 Platelet-platelet interaction, 285 Platelets characteristics of, 250 a-granule in, 286, 322 gray platelets, 286 Pneumocystis carinii, prophylactic antibiotics for, 716

Pneumonia, and pulmonary infarction, differentiation between, 161t Pneumonitis interstitial, complication of stem cell transplantation, 685 late effects of childhood cancer, 757-758 Polyarteritis nodosa, hematologic manifestations, 77

Polycythemia cause of unconjugated hyperbilirubinemia, 18t in childhood causes, 204t combined characteristics, 205 primary polycythemia, 202 secondary polycythemia, 202, 205 pathogenesis of, 203/ treatment, 205-207 Chuvashian polycythemia (CP), clinical manifestations of, 205, 206t in heart disease, 72 in the newborn, 199-202 causes of, 200t definition of, 199 factors increasing viscosity, 200t incidence, 199 laboratory findings polycythemia due to intrauterine hypoxia, 202

polycythemia due to maternofetal transfusion, 200-201 symptoms, signs, and complications, 201t treatment, 202 primary familial and congenital polycythemia

(PFCP), clinical manifestations of, 206t Von Hippel-Lindau mutations in, 205 Polycythemia vera clinical manifestations, 206t criteria for diagnosis of, 207t in high-risk patients, 206-207 intermediate-risk patients, 207 in low-risk patients, 206 Polymyositis, in Hodgkin disease, 465 "Popcorn cells," 457 Porcine factor VIII concentrate, 318t, 319 Positron emission tomography (PET), central nervous system malignancies, 516-517 Posterior fossa PNET. See Medulloblastoma Post-splenectomy infection, 711 Post-transplant LPDs characteristics in post-solid organ transplantation and post-hematopoietic stem cell transplantation, 380t classification of, 378t common sites of involvement in B-cell PTLDs, 379t diagnosis of, 377-378 treatment of B-cell LPD in immunosuppressed patients,

379, 381-382 chemotherapy, 379, 382t WHO classification of, 378t PPNET, 596, 597t Prednisone treatment

Diamond-Blackfan anemia, 99 infectious mononucleosis, 245 Pregnancy late effects of childhood cancer, 766 venous thrombosis and, 338 Priapism in SCD, 167-168 Primary familial and congenital polycythemia

(PFCP), clinical manifestations of, 206t Primitive neuroectodermal tumor (PNET), 596, 597t

Proliferating cell nuclear antigen (PCNA), 597 Protein C deficiency, 346

Protein deficiency, hematologic manifestations, 85 Protein S deficiency, 346-347 Prothrombin complex concentrate (PCC), treatment in hemophilia, 318, 318t Prothrombin G20210A mutation, 345 Pseudolymphoma, orbit and conjunctiva, 372 Pseudoneutropenia, 225-226 Pseudoxanthoma elasticum, 291

Psoriasis, hematologic manifestations, 76 Psychosocial support, in cancer patients, 747 Puberty, precocious, late effects of childhood cancer, 764, 765t Pulmonary disease hematologic manifestations, 75-76 with Hodgkin disease, 461 Pulmonary embolism, diagnosis of, 333t Pulmonary infarction and pneumonia, differentiation between, 161t Pulmonary syndrome, 608 Purpura factitia, 255t, 294 Purpura fulminans, 255t, 307t Pyknocytosis, infantile, 6t, 16 Pyropoikilocytosis, hereditary, 148-149 Pyruvate kinase deficiency, 152

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