Mtx Hc

Cytarabine G-CSF

15 mg/m2 PO q6h x 12 doses6 15 mg ITa

250 mg/m2/dose IV q12h 60 mg/m2 IV 6-h infusion

3 g/m2 (over 3 hours) IV 15 mg/m2 PO q6h x 12 doses6 100 mg/m2/day 24 continuous

IV infusion 15 mg IT" 15 mg IT" 30 mg IT" 5 ^g/kg/day SQ

Day 1

Day 1

Days 2-4

Days 2 and 6

Days 2-4 (6 doses total)

Day 2

(after cyclophosphamide) Days 1-5 Day 7 until ANC >3000/mm3

Day 1 Days 2-4

Days 2-6, inclusive Day 2

Days 2 and 7 Day 7

Day 7 until ANC

>3000/mm3

aAge-adjusted doses for intrathecal use:

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