In prepubertal and adult males, there is an 80-100% incidence of azoospermia after 5-6 cycles of MOPP. Twenty percent of these patients recover spermatogen-esis 7 years after therapy. A 50% incidence of sterility occurs after 3 cycles of MOPP. Leydig cell damage due to the use of MOPP in boys (ages 11-16 years) results in gynecomastia, reduced testosterone level, and elevated levels of FSH and LH.

Table 27-11. Effect of Fractionated Testicular Irradiation on Spermatogenesis and Leydig Cell Function

Testicular dose in Gy (100 rad)

Effect on spermatogenesis

Effect on Leydig cell function

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