Qtw

6-Mercaptopurine Purinethal, 6-MP PO

6-Thioguanine 6-TG PO

Hydroxyurea Hydrea PO

Cytarabine

Cytosine arabinoside Cytosar, Ara-C

Dose/m2 Schedule

Toxicities

250-1800 mg Daily x 1-4, q 21-28 days

100-300 mg Daily

1800 mg Daily x 5, q 21-28 days

16 mg Every 2 weeks x 4 then every 4 weeks

140-200 mg Single dose (ABMT)

100-150 mg Single dose, q 4-6 weeks

200-250 mg Single dose, q 4-6 weeks

50-200 mg Over 4-6 hours, q 21-28 days

560 mg q 28 days

175 mg Weekly x 4, q 6 weeks

250 mg Daily x 5, q 21-28 days

100 mg Daily for 10-14 days

1.8 mg Daily

M, N and V, A, phlebitis, vesicant, mucositis; NT (HD) M, N and V, A, cystitis, water retention; cardiac (HD) M, N and V, A, cystitis, NT, renal M, N and V; mucositis and diarrhea (HD)

M, N and V, renal and pulmonary M, N and V, renal and pulmonary M (mild), N and V, A, renal, NT, ototoxicity, allergic M (Pit), N and V, A, hepatic (mild)

M (mild), N and V, flulike syndrome, hepatic

M, N and V, NT, rash, mucositis M, A, pulmonary; N and V, mucositis, NT, hepatic (HD)

Weekly or biweekly Bolus or CI (6—42 hours) Daily

Daily or 2 x day Daily titrated to effect ql2 h or CI for 5-7 days ql2 h for 4-6 doses

M (mild), mucositis, rash, hepatic;

renal, NT (HD) M, hepatic, mucositis M, N and V, mucositis, hepatic M, N and V, diarrhea, A, renal toxicity

M, N and V, mucositis, GI, hepatic; NT, ocular, skin (HD)

5-Fluorouracil

Antibiotics Adriamycin

Daunomycin Bleomycin

Dactinomycin

Idarubicin

Mitoxantrone

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