The reduction in AFP level is a good predictor of outcome in patients with unre-sected tumors who undergo chemotherapy initially because of unresectability. A report from the Children's Cancer Group demonstrated that patients who showed a decline in AFP by 2 logs in the initial four courses of chemotherapy had a 75% survival.

Studies of DNA content have shown that diploid tumors with low proliferation index have a better prognosis than aneuploid tumors and high proliferative index.

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