"Adjustments of time schedule are made for clinical condition and marrow recovery.
Tatients with less than 70% response at day 33 (Initial tumor volume - tumor volume day 33)
are treated as high-risk ALL. v
^Additional doses at days 8 and 22 for CNS-positive patients. eDoses adjusted for children less than 3 years of age as follows: Methotrexate intrathecal
Initial tumor volume
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