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history of ileal resection, Crohn disease, lymphoma

"Either absent secretion of immunologically recognizable IF or secretes immunologically reactive protein that is inactive physiologically. The latter group includes patients whose IF has reduced affinity for the ileal IF receptor, reduced affinity for cobalamin, or increased susceptibility for proteolysis.

"Rare cases have been described of this syndrome associated with generalized malabsorption reversed by vitamin B12 administration, and rare cases have been described without protein-uria or aminoaciduria.

"Either absent secretion of immunologically recognizable IF or secretes immunologically reactive protein that is inactive physiologically. The latter group includes patients whose IF has reduced affinity for the ileal IF receptor, reduced affinity for cobalamin, or increased susceptibility for proteolysis.

"Rare cases have been described of this syndrome associated with generalized malabsorption reversed by vitamin B12 administration, and rare cases have been described without protein-uria or aminoaciduria.

other proteins to be endocytosed in the intestine and kidney. The exact function of AMN is unknown but mutations affecting either of the two proteins may cause Imerslund-Grasbeck syndrome. Table 4-4 lists the inborn errors of cobalamin transport and metabolism.

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