In courses A and B, 10% of the MTX dose of 500 mg/m2 (= 50 mg/m2) is administered IV over 30 minutes and

90% (= 450 mg/m2) as a 23.5-hour continuous IV infusion. Leucovorin 15 mg/m2 is administered as a bolus at 48, 51, and 54 hours.

In courses AA and BB, the MTX dose is increased to 5 g/m2. The infusion schedule and leucovorin rescue are the same as in protocol for non-B-cell lymphoma (see Table 16-6 footnote).

cMay be replaced with vinblastine 6 mg/m2 if vindesine is not commercially available.

From Seidemann K, Tiemann M, Schrappe M, et al. Short-pulse B-non Hodgkin lymphoma-type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Munster Group Trial NHL-BFM 90. Blood 2001;97:3699-3706, with permission.



Therapy Course

I, II-resected

II-not resected, III

IV or multiple bone involvement

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