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Abbreviations: LP, lymphocyte predominant; NS, nodular sclerosis; MC, mixed cellularity; LD, lymphocyte depletion; UC, unclassifiable Hodgkin disease; IF, interfollicular Hodgkin disease. From Donaldson SS, Link MP. Pediatr Clin North Am 1991;38:457-73, with permission.

Abbreviations: LP, lymphocyte predominant; NS, nodular sclerosis; MC, mixed cellularity; LD, lymphocyte depletion; UC, unclassifiable Hodgkin disease; IF, interfollicular Hodgkin disease. From Donaldson SS, Link MP. Pediatr Clin North Am 1991;38:457-73, with permission.

been known as Reed-Sternberg cells. The mononucleated blasts have been designated as Hodgkin cells. In 1955, Lukes and Butler described a multilobated variant of the Hodgkin and Reed-Sternberg cells that occurs mainly in the nodular lymphocyte-predominant type of Hodgkin disease. These multilobated blasts were called lymphocytic and/or histiocytic (L&H) cells because in lymphocyte-predominant Hodgkin disease the cellular background consists of lymphocytes and histiocytes. The multilobated nuclear morphology of these cells causes them to be referred to as "popcorn cells."

Immunohistologic studies have shown that two distinct immunophenotypes of atypical blasts exist in HD (Table 15-4):

1. Immunophenotype I is characterized by the consistent expression of CD20 and J chain, and the constant absence of CD30 and CD15 with the presence of L&H cell (LPHD).

2. Immunophenotype II is characterized by the constant expression of CD30, frequent expression of CD15, and constant absence of J chain with presence of Reed-Sternberg and Hodgkin cells (classic Hodgkin disease).

Table 15-5 lists the immunophenotypic markers in HD compared with other lymphomas.

Table 15-4. The Two Immunophenotypes of Neoplastic Cells

Encountered in Hodgkin Disease and Their Correlation with the Morphologically Distinct L&H Cell and Classic Hodgkin and Reed-Sternberg Cell Types

Immunophenotype I Immunophenotype II

lymphocyte-predominant classic Hodgkin disease

Hodgkin disease

Table 15-4. The Two Immunophenotypes of Neoplastic Cells

Encountered in Hodgkin Disease and Their Correlation with the Morphologically Distinct L&H Cell and Classic Hodgkin and Reed-Sternberg Cell Types

Immunophenotype I Immunophenotype II

lymphocyte-predominant classic Hodgkin disease

Hodgkin disease

Antigen

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