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hematopoietic cells

cells

"Differentiated, nondividing cells, but highly radiosensitive.

From Kun LE. General principles of radiation therapy. In: P.A. Pizzo and D.G. Poplack, editors. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott-Raven, 1997;289-321, with permission.

"Differentiated, nondividing cells, but highly radiosensitive.

From Kun LE. General principles of radiation therapy. In: P.A. Pizzo and D.G. Poplack, editors. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott-Raven, 1997;289-321, with permission.

• Discrepancy in length of extremities

• Alteration in sitting to standing height ratio.

These late consequences are related to the dose, site, volume, and age of the child at the time of radiation. The higher the dose and the younger the child, the more pronounced the late effects.

Prevention

• Low-volume, low-dose radiation combined with effective systemic therapy (e.g., treatment for Hodgkin disease in children, treatment of early-stage Wilms' tumor with chemotherapy alone)

• Improvement in the delivery of radiation with advances in radiation technology

• Dental prophylaxis prior to radiotherapy in maxillofacial site.

Management

• Length discrepancy: contralateral epiphysiodesis, limb-shortening procedures

• Pathologic fracture: surgical repair of fracture; may require internal fixation

• Osteonecrosis: symptomatic care, joint replacement.

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