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blood or bone marrow cells.

Adapted from Young NS, Bressler M, Casper JT, Liu J. Biology and therapy of aplastic anemia. In: Schacter GP, McArthur TR, editors. Hematology 1996. American Society of Hematology, 1996; with permission.

Adapted from Young NS, Bressler M, Casper JT, Liu J. Biology and therapy of aplastic anemia. In: Schacter GP, McArthur TR, editors. Hematology 1996. American Society of Hematology, 1996; with permission.

PNH type I = Normal expression of CD59

PNH type II = Partially deficient or residual expression of CD59

PNH type III = Complete absence of expression of CD59.

The proportion of the three different phenotypes may vary from patient to patient. Because other blood cell lineages can be analyzed, the transfusion of red blood cells to a patient does not interfere with the diagnosis of PNH.

The percentage of granulocytes with a PNH phenotype is usually higher than the percentage of red cells lacking CD59. Thus, flow cytometric analysis of the granulo-cytes increases sensitivity in the diagnosis of PNH.

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