Immunophenotypic Features

Carl Sternberg in 1898 and Dorothy Reed in 1902, independently of each other, reported the cytologic features of the multinucleated giant cells, which have since

Table 15-2. Comparison of Revised European-American Classification (REAL) and Rye Classification of Hodgkin Disease

REAL classification Rye classification

Lymphocyte predominant, nodular

(with or without diffuse) Classic Hodgkin disease

Lymphocyte-rich classic disease Nodular sclerosis Mixed cellularity Lymphocyte depletion aParentheses indicate relative frequency of disease.

From DeVita VT Jr, Mauch PM, Harris NL. Hodgkin's disease. In: DeVita VT Jr, Hellman S, Rosenberg SA, editors. Cancer Principles and Practice of Oncology. Philadelphia: Lippincott-Raven, 1997:2242-83, with permission.

Lymphocyte predominance, nodular l Lymphocyte predominance, diffuse J ( 0) Nodular sclerosis (40-60%) Mixed cellularity (15-30%) Lymphocyte depletion (<5%)

Table 15-3. Histopathologic Classification of Hodgkin Disease by Age Group

Age group

LP (%)

NS (%)

MC (%)

LD (%)

UC/IF (%)

<10 years

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