Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) is the most common of the inherited vascular disorders. The disease is inherited as an autosomal dominant trait and bleeding occurs from vascular lesions on the skin or mucous membranes. Lesions consist of dilated arterioles and capillaries lined by a thin endothelial layer. They are typical in appearance (1-3 mm in diameter, flat, round, and red or violet in color), and they blanch on pressure. Histology of the abnormal vessels shows a deficiency of supporting elastic fibers. Typical lesions occur most often on the nasal mucosa, lips, oral mucosa, tongue, face, hands, gastrointestinal tract, and, rarely, in the respiratory, gynecological, and urinary tracts. Epistaxis is usually the most common symptomatology.
Was this article helpful?
Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.