Hereditary Disorders Of Platelet Function

Qualitative disorders of platelet function (see Chapter 10) usually manifest with mucocutaneous bleeding. Symptoms include petechiae, ecchymoses, epistaxis, men-orrhagia, gastrointestinal bleeding, and abnormal bleeding in association with injury or trauma. Physical examination may reveal associated abnormalities such as nystagmus and oculocutaneous albinism in Hermansky-Pudlack syndrome or eczema in Wiskott-Aldrich syndrome. Laboratory evaluation includes morphologic inspection of the blood smear for platelet size, inclusions, and the presence of a gray or washed-out appearance. Assessment of platelet function by bleeding time, platelet aggregation studies, or PFA-100 closure time will usually be abnormal. Definitive diagnosis of suspected disorders will often require additional studies available only at reference laboratories (e.g., flow cytometry enumeration of receptors, electron

Table 11-21. Treatment of Rare Coagulation Factor Deficiencies"

Percentage increase in

Percentage increase in

Table 11-21. Treatment of Rare Coagulation Factor Deficiencies"

Curing Eczema Naturally

Curing Eczema Naturally

Do You Suffer From the Itching, Redness and Scaling of Chronic Eczema? If so you are not ALONE! It strikes men and women young and old! It is not just

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