Hematologic Manifestations Of Systemic Illness

A variety of systemic illnesses including acute and chronic infections, neoplastic diseases, connective tissue disorders, and storage diseases are associated with hema-tologic manifestations. The hematologic manifestations are the result of the following mechanisms:

1. Bone marrow dysfunction a. Anemia or polycythemia b. Thrombocytopenia or thrombocytosis c. Leukopenia or leukocytosis

2. Hemolysis

3. Immune cytopenias

4. Alterations in hemostasis a. Acquired inhibitors to coagulation factors b. Acquired von Willebrand disease c. Acquired platelet dysfunction

5. Alterations in leukocyte function.

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