Bone Marrow Aplasia
All causes of constitutional aplastic anemia may present with thrombocytopenia in the newborn (see Chapter 6).
Hyperglycinemia with ketosis and the closely related metabolic disorder of methyl-malonic acidemia may cause periodic thrombocytopenia, as well as neutropenia, during infancy. Infants with these metabolic disorders present with lethargy, vomiting, and ketosis during the neonatal period. A similar disorder, isovaleric acidemia, is associated with a generalized marrow hypoplasia causing thrombocytopenia and neu-tropenia. Neonatal thrombocytopenic purpura has been reported in infants born to hyperthyroid mothers. The mechanism has not been defined.
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