Folate coenzymes are the central participants in single-carbon transfer reactions. 5,10-Methylene tetrahydrofolate is used unchanged for the synthesis of thymidylate,
*In this form of cobalamin, the cobalt atom is trivalent (cob) and must be reduced before it can bind to the respective enzyme.
reduced to 5-methyltetrahydrofolate for the synthesis of methionine, or oxidized to 10-formyltetrahydrofolate for the synthesis of purines. The causes of folic acid deficiency are listed in Table 4-6.
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