Foam cells are seen in the bone marrow in the following conditions:
3. Gm1 gangliosidosis (type 1)
4. Gm2 gangliosidosis (Sandhoff variant)
5. Lactosyl ceramidosis
6. Sialidosis I
7. Sialidosis II, late infantile type
8. Mucolipidosis II
9. Mucolipidosis III
10. Mucolipidosis IV
13. Neuronal ceroid-lipofuscinosis
14. Farber disease
15. Wolman disease
16. Cholesteryl ester storage disease
17. Cerebrotendinous xanthomatosis
18. Chronic hyperlipidemia
19. Chronic corticosteroid therapy
20. Hematologic malignancies (e.g., Hodgkin disease, leukemia, myeloma)
21. Hematologic disease (e.g., aplastic anemia, ITP).
A careful history (including ethnic and family history), physical examination, examination of bone marrow using phase electron microscopy and special stains, and liver biopsy for biochemical analysis (enzyme assays on white blood cells or cultured skin fibroblasts) can assist in making a specific diagnosis of these storage diseases.
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