Foam Cells in Bone Marrow

Foam cells are seen in the bone marrow in the following conditions:

3. Gm1 gangliosidosis (type 1)

4. Gm2 gangliosidosis (Sandhoff variant)

5. Lactosyl ceramidosis

6. Sialidosis I

7. Sialidosis II, late infantile type

8. Mucolipidosis II

9. Mucolipidosis III

10. Mucolipidosis IV

11. Fucosidosis

12. Mannosidosis

13. Neuronal ceroid-lipofuscinosis

14. Farber disease

15. Wolman disease

16. Cholesteryl ester storage disease

17. Cerebrotendinous xanthomatosis

18. Chronic hyperlipidemia

19. Chronic corticosteroid therapy

20. Hematologic malignancies (e.g., Hodgkin disease, leukemia, myeloma)

21. Hematologic disease (e.g., aplastic anemia, ITP).

A careful history (including ethnic and family history), physical examination, examination of bone marrow using phase electron microscopy and special stains, and liver biopsy for biochemical analysis (enzyme assays on white blood cells or cultured skin fibroblasts) can assist in making a specific diagnosis of these storage diseases.

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