Table 9-12 lists the nonclonal (reactive) causes of eosinophilia, and Figure 9-2 shows the nonclonal (reactive) and clonal causes of eosinophilia.
Table 9-12. Nonclonal (Reactive) Causes of Eosinophilia
Omenn syndrome (severe combined immunodeficiency and eosinophilia) Skin disorders
Helminthic: Ascaris lumbricoides," trichinosis, echinococcosis, visceral larva migrans,ab hookworm,a strongyloidiasis,a filariasisa Protozoal: malaria, pneumocystis, toxoplasmosis Hematologic disorders
Hodgkin disease, postsplenectomy state, eosinophilic leukemoid reaction, congenital immune deficiency syndromes, Fanconi anemia, thrombocytopenia with absent radii, Kostmann disease, infectious mononucleosis, familial reticuloendotheliosis Familial eosinophilia Irradiation
Eosinophilic pneumonitis (Loeffler syndrome), pulmonary eosinophilia with asthma, tropical eosinophilia
Table 9-12. (Continued)
Idiopathic hypereosinophilic syndrome,b periarteritis nodosa, metastatic neoplasm, cirrhosis, peritoneal dialysis, chronic renal disease, Goodpasture syndrome, sarcoidosis, thymic disorders, hypoxia Idiopathic
"Helminth infestations associated with eosinophilia and pulmonary infiltrates.
^Conditions associated with striking eosinophilia. Leukocyte counts of 30,000-100,000/mm3 are characteristic, with 50-90% of leukocytes being eosinophils. In all other conditions, the white blood cell count is normal or only slightly elevated, and eosinophils make up 10-40% of the leukocyte count.
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If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.