Eosinophils

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Table 9-12 lists the nonclonal (reactive) causes of eosinophilia, and Figure 9-2 shows the nonclonal (reactive) and clonal causes of eosinophilia.

Table 9-12. Nonclonal (Reactive) Causes of Eosinophilia

Allergic disorders

Asthma, hay fever, urticaria, drug hypersensitivity Immunologic disorders

Omenn syndrome (severe combined immunodeficiency and eosinophilia) Skin disorders

Eczema, scabies, erythema toxicum, dermatitis herpetiformis, angioneurotic edema, pemphigus Parasitic infestation

Helminthic: Ascaris lumbricoides," trichinosis, echinococcosis, visceral larva migrans,ab hookworm,a strongyloidiasis,a filariasisa Protozoal: malaria, pneumocystis, toxoplasmosis Hematologic disorders

Hodgkin disease, postsplenectomy state, eosinophilic leukemoid reaction, congenital immune deficiency syndromes, Fanconi anemia, thrombocytopenia with absent radii, Kostmann disease, infectious mononucleosis, familial reticuloendotheliosis Familial eosinophilia Irradiation

Pulmonary eosinophilia

Eosinophilic pneumonitis (Loeffler syndrome), pulmonary eosinophilia with asthma, tropical eosinophilia

Table 9-12. (Continued)

Gastrointestinal disorders

Eosinophilic gastroenteritis, milk precipitin disease, ulcerative colitis, protein-losing enteropathy, regional enteritis, allergic granulomatosis Miscellaneous

Idiopathic hypereosinophilic syndrome,b periarteritis nodosa, metastatic neoplasm, cirrhosis, peritoneal dialysis, chronic renal disease, Goodpasture syndrome, sarcoidosis, thymic disorders, hypoxia Idiopathic

"Helminth infestations associated with eosinophilia and pulmonary infiltrates.

^Conditions associated with striking eosinophilia. Leukocyte counts of 30,000-100,000/mm3 are characteristic, with 50-90% of leukocytes being eosinophils. In all other conditions, the white blood cell count is normal or only slightly elevated, and eosinophils make up 10-40% of the leukocyte count.

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