The hypothalamic-pituitary axis plays a central role in translating neurologic and chemical signals from the brain into endocrine responses through its neuronal circuitry with the brain involving afferent and efferent pathways. It also produces peptide hormones and biogenic amines that serve as regulators of anterior pituitary hormones. These hypothalamic factors are supplied to the anterior pituitary gland by way of the portal venous system.
Table 27-9 shows the anterior pituitary hormones, their physiologic functions, and their hypothalamic regulatory hormones.
Table 27-10 describes the neuroendocrine complications, their clinical manifestations, standard fractionated radiation dose limits responsible for brain damage, diagnostic studies, and treatment.
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