Cell

TARGET OF APC & Tcells

Peptide HA-1 or HA-2 or HY-1

BCR/ABL antigen-specific Tcell Proteinase 3-specific Tcells mHA antigen-specific T cells

VARIOUS SUBSETS OF ANTIGEN-SPECIFIC CYTOTOXIC CD8+ TCELLS IMPLICATED IN GRAFT VERSUS LEUKEMIA REACTION IN CML

Fig. 13-5. Some of the cellular mechanisms involved in graft versus leukemia reaction following allogeneic HSCT in CML (see text for explanation). Note: Numbers in parentheses correspond to description in text.

II and MHC class I, respectively. APCs may be derived from recipient's CML stem cells or from donor's stem cells. 3. The immune response generates expanded population of antigen-specific CD8+ cytotoxic T cells. Specific antigens implicated in the GVL response in CML are as follows:

Antigen

Protein

Peptide

Minor histocompatibility antigens

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