Ade

Course S MACE

Course 4 MidAC

Daunorubicin 50 mg/m2 IV days 1, 3, 5

Cytosine arabinoside 100 mg/m2 IV bolus every 12 hours days 1-10 Etoposide 100 mg/m2 IV (1-hour infusion) days 1-5 Daunorubicin 50 mg/m2 IV days 1, 3, 5

Cytosine arabinoside 100 mg/m2 IV bolus every 12 hours days

1-8 (16 doses) Etoposide 100 mg/m2 IV (1-hour infusion) days 1-5 Amsacrine 100 mg/m2 IV (1-hour infusion) days 1-5 Cytosine arabinoside 200 mg/m2/d IV (continuous infusion) days 1-5

Etoposide 100 mg/m2 IV (1-hour infusion) days 1-5 Mitoxantrone 10 mg/m2 IV (short infusion) days 1-5 Cytosine arabinoside 1.0 gram/m2 12-hourly IV (2 hour infusion) days 1-3

All doses are reduced by 25% for children less than 1 year of age.

Adapted from Stevens RF, Hann IM, Wheatley K, Gray RG. Marked improvement in outcome with chemotherapy alone in paediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council's 10th AML trial. Br J Haematol 1998;101:130-40.

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