Acute Myeloid Leukemia

The age incidence of AML in childhood is constant except for a peak of incidence in the neonatal period and a slight increase in incidence during adolescence. The following inherited disorders predispose a patient to AML:

Down syndrome Fanconi anemia Kostmann syndrome Bloom syndrome Diamond-Blackfan anemia.

Secondary AML can evolve from:

Myelodysplastic syndromes and myeloproliferative syndromes (Chapter 13) Exposure to ionizing radiation treatment with chemotherapy agents. The following are chemotherapy agents associated with secondary AML: Nitrogen mustard Cyclophosphamide Ifosfamide Chlorambucil Melphalan Etoposide.

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