Juvenile Myelomonocytic Leukemia

Blastic Bone Metastases

Incidence 1.2 per million children per year Median age at diagnosis 1.8 years 35 below 1 year of age, and only 4 above 5 years of age Male female ratio of 2 1 Association with neurofibromatosis type 1 NF-1 Children with NF-1 have more than a 200-fold increased risk of JMML. Fifteen percent of children with JMML have NF-1. Children with Noonan syndrome or trisomy 8 mosaicism are at increased risk of developing JMML. Most cases of neonates with Noonan syndrome with JMML-like presentation resolve...