Pathogenetic Aspects

Beta Switch Program

The Beta Switch Program by Sue Heintze

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These statistical observations imply a major, fundamental, systematic pathogenetic background to abdominal, visceral fat accumulation and its associated multiple comorbidities. From a clinical point of view, there is a perceptible resemblance between this condition and that of Cushing's syndrome. In fact, subjects with abdominal, visceral obesity share many of the metabolic, hormonal, circulatory and behavioural findings observed in Cushing's syndrome. It may therefore be suspected that the regulation of cortisol secretion is involved in the syndrome of visceral obesity (5,14).

Studies driven by this hypothesis suggested that urinary cortisol output was elevated with elevated WHR (15). Although statistically significant, the original findings were strongly influenced by a few extreme observations. It is also clear that the cortisol output is frequently normal or even low in subjects with elevated WHR (Figure 1 in reference 15). Results of other studies indicated that when the hypothalamic-pituitary-adrenal (HPA) axis, regulating cortisol secretion, was stimulated at the levels of the adrenals with adrenocorticotropic hormone (ACTH), the pituitary with corticotrophin-releasing hormone (CRH) and the hypothalamic centres by laboratory stress, the total urinary output of cortisol appeared to be elevated in subjects with high WHR (15,16). However, the challenges at the different levels of the HPA axis were performed with maximal doses of ACTH and CRH. The use of such doses provides information about the responsiveness rather than sensitivity of the regulatory system. Maximal stimulation rarely, if ever, occurs under ordinary, everyday life conditions, and these results therefore had minor significance for the issue addressed.

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Fire Up Your Core

Fire Up Your Core

If you weaken the center of any freestanding structure it becomes unstable. Eventually, everyday wear-and-tear takes its toll, causing the structure to buckle under pressure. This is exactly what happens when the core muscles are weak – it compromises your body’s ability to support the frame properly. In recent years, there has been a lot of buzz about the importance of a strong core – and there is a valid reason for this. The core is where all of the powerful movements in the body originate – so it can essentially be thought of as your “center of power.”

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