Conclusions

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Is It Time to Enhance Investigation of the Means to Prevent Obesity?

Sufficient data currently exist from studies of animal models to demonstrate unequivocally the extraordinary power of obesity prevention to per manently alter the trajectory of a wide range of diseases, including but not limited to heart disease, type 2 diabetes, hypertension, cancer, and other aging-associated chronic diseases.

Public health approaches have to date proven to be too weak in efficacy to provide for strong positive cost-benefit conclusions related to widespread obesity treatment. Behavioral modification has had a small measure of success in a very limited number of humans, and the likelihood of strengthening these behavioral or environmental manipulations to a level sufficient to impact overall incidence of obesity is low. Biomedical approaches may, in the future, offer the potential power to alter the obesity trajectory and to change the negative health consequences of this extraordinarily prevalent disease.

Non-human primates in the study of obesity have offered numerous pointers to the human condition, some of which have been reviewed here. Together these findings offer an optimistic view of the future benefits of obesity mitigating efforts.

Figure 14.10 An insulin sensitizer of the thiazolidinedione class (R-102380) administered to four monkeys for more than 6 weeks induced a significant increase in the change in glycogen synthase activity induced by insulin (before and during a eu-glycemic hyperinsulinemic clamp). Both the glycogen synthase independent activity and the fractional activity of glycogen syn-thase were significantly increased (107)

Figure 14.10 An insulin sensitizer of the thiazolidinedione class (R-102380) administered to four monkeys for more than 6 weeks induced a significant increase in the change in glycogen synthase activity induced by insulin (before and during a eu-glycemic hyperinsulinemic clamp). Both the glycogen synthase independent activity and the fractional activity of glycogen syn-thase were significantly increased (107)

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