Skeletal Muscle Disease

A number of diseases can affect the contraction of skeletal muscle. Many of them are due to defects in the parts of the nervous system that control contraction of the muscle fibers rather than to defects in the muscle fibers themselves. For example, poliomyelitis is a viral disease that destroys motor neurons, leading to the paralysis of skeletal muscle, and may result in death due to respiratory failure.

Muscle Cramps Involuntary tetanic contraction of skeletal muscles produces muscle cramps. During cramping, nerve action potentials fire at abnormally high rates, a much greater rate than occurs during maximal voluntary contraction. The specific cause of this high activity is uncertain but is probably related to electrolyte imbalances in the extracellular fluid surrounding both the muscle and nerve fibers and changes in extracellular osmolarity, especially hy-poosmolarity.


Muscle Lever Action

Vm = muscle contraction velocity

Vm = muscle contraction velocity

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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