Figure 611

Primary active-transport model. Changes in the binding site affinity for a transported solute are produced by phosphorylation and dephosphorylation of the transporter (covalent modulation) as it oscillates between two conformations. See text for the numbered sequence of events occurring during transport. |Q]

Vander et al.: Human Physiology: The Mechanism of Body Function, Eighth Edition

PART ONE Basic Cell Functions

Intracellular fluid

Extracellular fluid

ATP mi^

3Na+

Essentials of Human Physiology

Essentials of Human Physiology

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